文章基本信息

标题：Structures to complement the archaeo-eukaryotic primases catalytic cycle description: What's next?
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作者：Julien Boudet ; Jean-Christophe Devillier ; Frédéric H.-T. Allain 等
期刊名称：Computational and Structural Biotechnology Journal
印刷版ISSN：2001-0370
出版年度：2015
卷号：13
页码：339-351
DOI：10.1016/j.csbj.2015.04.006
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出版社：Computational and Structural Biotechnology Journal
摘要：DNA replication is a crucial stage in the transfer of genetic information from parent to daughter cells. This mechanism involves multiple proteins with one key player being the primase. Primases are single-stranded DNA dependent RNA polymerases. On the leading strand, they synthesize the primer once allowing DNA elongation while on the lagging strand primers are generated repeatedly (Okazaki fragments). Primases have the unique ability to create the first phosphodiester bond yielding a dinucleotide which is initially elongated by primases and then by DNA polymerases.
关键词：Primases ; High-resolution structures ; Catalysis ; Dinucleotide formation ; DNA template ; Primer synthesis