文章基本信息

标题：Lung Cancer Therapy Targeting Histone Methylation: Opportunities and Challenges
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作者：Yuchen Chen ; Xinran Liu ; Yangkai Li 等
期刊名称：Computational and Structural Biotechnology Journal
印刷版ISSN：2001-0370
出版年度：2018
卷号：16
页码：211-223
DOI：10.1016/j.csbj.2018.06.001
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出版社：Computational and Structural Biotechnology Journal
摘要：Lung cancer is one of the most common malignancies. In spite of the progress made in past decades, further studies to improve current therapy for lung cancer are required. Dynamically controlled by methyltransferases and demethylases, methylation of lysine and arginine residues on histone proteins regulates chromatin organization and thereby gene transcription. Aberrant alterations of histone methylation have been demonstrated to be associated with the progress of multiple cancers including lung cancer. Inhibitors of methyltransferases and demethylases have exhibited anti-tumor activities in lung cancer, and multiple lead candidates are under clinical trials. Here, we summarize how histone methylation functions in lung cancer, highlighting most recent progresses in small molecular inhibitors for lung cancer treatment.
关键词：Histone methylation ; Histone demethylation ; Lung cancer ; Histone methyltransferase ; Histone demethylase ; Inhibitors