文章基本信息

标题：Regulatory Activities from Conjugated Linoleic Acid of p38 Protein in Melanoma Cells
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作者：Hyun Woo Kang ; Sang Jae Kwak
期刊名称：Journal of Food and Nutrition Research
印刷版ISSN：2333-1119
电子版ISSN：2333-1240
出版年度：2019
卷号：7
期号：3
页码：183-186
DOI：10.12691/jfnr-7-3-1
出版社：Science and Education Publishing
摘要：This study investigated the activities of trans10,cis12-conjugated linoleic acid (CLA) were then passed through the p38 in in vitro model. Cell viability, apoptosis, expression of p38 was evaluated using B16 melanoma cells. Our result showed that the trans10,cis12-CLA increased cell apoptosis in melanoma cells. In addition, CLA stimulated the expression of p38 and phosphorylation p38 (p-p38) level using western blotting. The p38 was presumed that the CLA were involved in regulation of apoptosis-related pathway in the melanoma cells signaling pathway. Considering the results obtained, the present study finding that the regulatory activities of trans10,cis12-CLA may be important as a therapeutic target in ameliorating melanoma cells mediated cancer or/and tumor on in vitro model.
关键词：conjugated linoleic acid; p38; melanoma cells; cell apoptosis