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标题：Effect of Levisticum officinale Hydroalcoholic Extract on DU-145 and PC-3 Prostate Cancer Cell Lines
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作者：Saman Sargazi ; Ramin Saravani ; HamidReza Galavi 等
期刊名称：Gene, Cell and Tissue
印刷版ISSN：2345-6841
出版年度：2017
卷号：4
期号：4
DOI：10.5812/gct.66094
出版社：Zahedan University of Medical Sciences
摘要：Levisticum officinale contains a variety of components used for its medicinal properties in traditional medicine. The previous studies showed that it had an anti-cancer effect on cell lines. The current study aims to evaluate the cytotoxic potential of Levisticum officinale hydroalcoholic extract (LOHE) on DU-145 and PC-3 human advanced prostate cancer cell lines. The anti-proliferative activity of LOHE was evaluated using the MTT assay. The results of MTT showed that the IC50 of DU-145 and PC-3 were 500 µg/mL and 400 µg/mL of LOHE, respectively, following 24 hours treatment. This study found that the hydroalcoholic extract of Levisticum officinale had beneficial cell death inducing effects on both the PC3 and DU145 human prostate carcinoma cell lines in time- and concentration-dependent fashion. Hence, LOHE may have remarkable potential for uses as new natural anticancer agent.
关键词：Prostate Cancer; Cytotoxic Effects; Cell Death; Levisticum officinale