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标题：Association of Genetic Variations in XRCC1 and ERCC1 Genes with Sporadic Breast Cancer
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作者：Saeid Ghorbian ; Mansooreh Nargesian ; Sasan Talaneh 等
期刊名称：Gene, Cell and Tissue
印刷版ISSN：2345-6841
出版年度：2018
卷号：5
期号：2
DOI：10.5812/gct.80166
出版社：Zahedan University of Medical Sciences
摘要：Background: Recently, findings have validated the significant role of DNA damage genes related to the pathogenesis of breast cancer (BC). The aim of the present investigation was to evaluate possibility roles of two common XRCC1 (rs25487; A > G) and ERCC1 (rs3212964; A > G) gene polymorphisms with the risk of sporadic BC. Methods: In a case-control study, consisting of 100 females identified with sporadic BC and 100 malignancy-free females as the control group. We used Tetra-ARMS Polymerase Chain Reaction (PCR) and PCR-Restriction Fragment Length Polymorphism (RFLP) methods to determine genotype frequencies of XRCC1 and ERCC1 genes. Results: The findings did not reveal a statistically significant difference in the genotype frequencies of XRCC1 and ERCC1 genes between the two groups (P > 0.05). The frequency of G mutant allele for XRCC1 and ERCC genes was higher in cases compared to controls, while the difference between the groups was not statistically significant (P = 0.202; OR: 1.312; CI: 0864 - 1.994), (P = 0.352; OR: 1.213; CI: 0.808 - 1.820). Conclusions: The current results provide evidence against the hypothesis that XRCC1 (rs25487) and ERCC1 (rs3212964) gene polymorphisms may be associated with a predisposition to sporadic BC.
关键词：XRCC1 ; Breast Cancer; ERCC1 ; DNA Repair