文章基本信息

标题：Critical Roles of Non-coding RNAs in Acute Lymphoblastic Leukemia
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作者：Maryam Mazloumi Gavgani ; Mansooreh Nargesian ; Saeid Ghorbian 等
期刊名称：Gene, Cell and Tissue
印刷版ISSN：2345-6841
出版年度：2018
卷号：5
期号：4
DOI：10.5812/gct.83297
出版社：Zahedan University of Medical Sciences
摘要：MicroRNA (miRNA) is one of the non-coding RNA (ncRNA) molecules with 21 - 25-nucleotide length, playing an important role in gene control by transcriptional gene regulation, chromatin remodeling, genetic imprinting, and translation initiation. The deregulation of ncRNA can lead to several hematopoietic malignancies such as acute lymphoblastic leukemia (ALL). The study aimed to draw the crucial features of miRNA in the pathogenesis of ALL. The findings showed that miRNA expression changes in ALL are typical and involve several signaling pathways. The variations in miRNA gene expression can lead to the incomplete expression of oncoprotein or tumor suppressor gene (TSG). It seems that ncRNAs play pivotal roles in the ALL pathogenesis. However, ncRNAs might be interested as potential diagnostic and prognostic biomarkers in ALL.
关键词：ncRNA; miRNA; ALL; Acute Lymphoblastic Leukemia