文章基本信息

标题：Development of a Potent Protein Degrader against Oncogenic BCR-ABL Protein
本地全文：下载
作者：Norihito Shibata ; Nobumichi Ohoka ; Takayuki Hattori 等
期刊名称：Chemical and Pharmaceutical Bulletin
印刷版ISSN：0009-2363
电子版ISSN：1347-5223
出版年度：2019
卷号：67
期号：3
页码：165-172
DOI：10.1248/cpb.c18-00703
出版社：The Pharmaceutical Society of Japan
摘要：Email communication is pervasive in faculty interaction. As there exists status imbalance between students and professors in this type of context, emails are expected to cater for the uneven power relationships by means of using appropriate polite features. Previous research (e.g., Eslami, 2013; Salazar-Campillo & Codina-Espurz, in press) has pointed out the pragmatically deficient use of openings and closings in requestive emails sent by non-native students in educational contexts, revealing a lack of the expected deference and respect to the professor. In this paper, we firstly explore this topic further by looking at different groups of emails written by CLIL students to ascertain whether this variable affects students’ pragmalinguistic and sociopragmatic ability when writing their emails. Secondly, a proposal for the teaching of openings and closings is suggested, which aims to help second and/or foreign language learners behave in a more target-like manner thus avoiding pragmatic failure.
关键词：BCR-ABL;chronic myelogenous leukemia (CML);degrader;E3 ubiquitin ligase;proteasome;protein knockdown