文章基本信息

标题：Panax notoginseng Saponins Attenuate Oxygen–Glucose Deprivation/Reoxygenation-Induced Injury in Human SH-SY5Y Cells by Regulating the Expression of Inflammatory Factors through miR-155
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作者：Lanqing Meng ; Jun Lin ; Qing Huang 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2019
卷号：42
期号：3
页码：462-467
DOI：10.1248/bpb.b18-00799
出版社：The Pharmaceutical Society of Japan
摘要：Drought frequency and intensity is expected to increase in many regions worldwide, and water shortages could become more extreme, even in humid temperate climates. To protect the environment and secure water supplies, water abstractions for irrigation can be mandatorily reduced by environmental regulators. Such abstraction restrictions can result in economic impacts on irrigated agriculture. This study provides a novel approach for the probabilistic risk assessment of potential future economic losses in irrigated agriculture arising from the interaction of climate change and regulatory drought management, with an application to England and Wales. Hydrometeorological variability is considered within a synthetic data set of daily rainfall and river flows for a baseline period (1977–2004) and for projections for near future (2022–2049) and far future (2072–2099). The probability, magnitude, and timing of abstraction restrictions are derived by applying rainfall and river flow triggers in 129 catchments. The risk of economic losses at the catchment level is then obtained from the occurrences of abstraction restrictions combined with spatially distributed crop‐specific economic losses. Results show that restrictions will become more severe, more frequent, and longer in the future. The highest economic risks are projected where drought‐sensitive crops with a high financial value are concentrated in catchments with increasingly uncertain water supply. This research highlights the significant economic losses associated with mandatory drought restrictions experienced by the agricultural sector and supports the need for environmental regulators and irrigators to collaboratively manage scarce water resources to balance environmental and economic considerations.
关键词：Panax notoginseng saponin;SH-SY5Y;microRNA (miR)-155;oxygen–glucose deprivation;reoxygenation;inflammatory factor