文章基本信息

标题：A Direct Quantitative Analysis of Erythrocyte Intracellular Ionized Magnesium in Physiological and Pathological Conditions
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作者：Wenxiang Xiong ; Yaru Liang ; Xue Li 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2019
卷号：42
期号：3
页码：357-364
DOI：10.1248/bpb.b18-00406
出版社：The Pharmaceutical Society of Japan
摘要：CO2 reservoirs and high CO2 content gas reservoirs in marine sediments generally have complex pressure system, which usually encounters supercritical CO2(SC‐CO2) invasion into the wellbore during drilling process. The wellbore transient flow and phase transition along the wellbore during the drilling process has not been thoroughly investigated, because the CO2 physical properties and the reservoirs petrophysical properties could affect the transient flow of mixed fluid and phase transition of CO2 along the well. A numerical model is presented in this research to analyze the transient flow in wellbores and to predict phase transition of CO2 during formation SC‐CO2 invasion in the drilling process. The main considerations were the following: multiphase transient flow in wellbores was coupled with the non‐Darcy flow through the formation; wellbore temperature, pressure and the mixture of drilling fluid and SC‐CO2 were calculated in the method of coupling; the invaded SC‐CO2 could affect the mixed fluid physical properties in the annulus; the change of physical properties of CO2 (eg, solubility, phase transition) was considered and integrated. The research results indicate that as the mixture of drilling fluid and SC‐CO2 flows from the bottom to the surface, the invaded CO2 is difficult to be detected at the early invasion stage because of high CO2 density and solubility; the CO2 would change from supercritical to gas phase and the dissolved quantity and density of CO2 rapidly decrease near the wellhead, and further cause well‐control issues. Furthermore, the bottom‐hole pressure (BHP) would decrease and could not provide sufficient balance to the formation pressure, which could significantly increase the risk of well blowout. Sensitivity analysis was utilized to evaluate the effects of the choke pressure, drilling fluid pumping rate, initial pressure difference, reservoir permeability, and drilled reservoir thickness on the BHP and the depth of phase transition of CO2.
关键词：magnesium deficiency;dietary magnesium regulation;acute magnesium intake test;aging;metabolic syndrome;erythrocyte intracellular ionized magnesium