文章基本信息

标题：Recent Advances in Liquid Biopsy in Precision Oncology Research
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作者：Yoshiharu Sato ; Ryo Matoba ; Kikuya Kato 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2019
卷号：42
期号：3
页码：337-342
DOI：10.1248/bpb.b18-00804
出版社：The Pharmaceutical Society of Japan
摘要：In this study, the effects of homogenization pressure (125, 145, and 165 bars) and temperature (45, 60, and 75°C) on the properties of Sesame vegetable cream are investigated. The physical stability of cream was characterized by droplet size and syneresis, and chemical stability of it was evaluated by determining peroxide value and p‐anisidine. The results showed that the cream in the presence of high pressure and temperature treatment exhibits lower stability. At 75°C temperature and 165 bar, the vegetable cream had highest peroxide value (3.61) and p‐anisidine (2.16). However, pressure could protect the droplets against aggregation in the high pressure (165 bar) and greatly increased the physical stability. During increase in process parameters, the syneresis of cream was decreased with a rise of pressure and extension of temperature. The process condition in 145 bar and 60°C led to the high acceptability of vegetable cream.
关键词：liquid biopsy;circulating tumor DNA;minimally invasive tumor genotyping;molecular barcoding technology;ultrarare mutation detection