文章基本信息

标题：Normalizing brain activity across individuals using functional reference mapping
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作者：Eugenio Martinelli ; Alja Lüdke ; Piergiorgio Adamo 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2017
卷号：7
期号：1
页码：17128
DOI：10.1038/s41598-017-16913-1
语种：English
出版社：Springer Nature
摘要：Neural activity can be mapped across individuals using brain atlases, but when spatial relationships are not equal, these techniques collapse. We map activity across individuals using functional registration, based on physiological responses to predetermined reference stimuli. Data from several individuals are integrated into a common multidimensional stimulus space, where dimensionality and axes are defined by these reference stimuli. We used this technique to discriminate volatile compounds with a cohort of Drosophila flies, by recording odor responses in receptor neurons on the flies' antennae. We propose this technique for the development of reliable biological sensors when activity raw data cannot be calibrated. In particular, this technique will be useful for evaluating physiological measurements in natural chemosensory systems, and therefore will allow to exploit the sensitivity and selectivity of olfactory receptors present in the animal kingdom for analytical purposes.