文章基本信息

标题：PilVax – a novel peptide delivery platform for the development of mucosal vaccines
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作者：Dasun Wagachchi ; Jia-Yun C. Tsai ; Callum Chalmers 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2018
卷号：8
期号：1
页码：2555
DOI：10.1038/s41598-018-20863-7
语种：English
出版社：Springer Nature
摘要：into 3 different loop regions of the backbone protein Spy0128, which resulted in the assembly of the pilus containing large numbers of peptide on the surface of L. lactis. Intranasal immunisation of mice with L. lactis PilM1-Ova generated measurable Ova-specific systemic and mucosal responses (IgA and IgG). Furthermore, we show that multiple peptides can be inserted into the PilVax platform and that peptides can also be incorporated into structurally similar, but antigenically different pilus structures. PilVax may be useful as a cost-effective platform for the development of peptide vaccines against a variety of important human pathogens.