文章基本信息

标题：In vivo effect of opticin deficiency in cartilage in a surgically induced mouse model of osteoarthritis
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作者：Aina Farrán ; Gladys Valverde-Franco ; Laura Tío 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2018
卷号：8
期号：1
页码：457
DOI：10.1038/s41598-017-18047-w
语种：English
出版社：Springer Nature
摘要：cartilage. The protective effect of OPTC deficiency during OA results from an overexpression of lumican and epiphycan, known to bind and protect collagen fibers, and a decrease in fibromodulin, contributing to a reduction in the complement activation/inflammatory process. This work suggests that the evaluation of the composition of the different SLRPs in OA cartilage could be applied as a new tool for OA prognosis classification.