文章基本信息

标题：Optimizing human Treg immunotherapy by Treg subset selection and E-selectin ligand expression
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作者：Conor Donnelly ; Brad Dykstra ; Nandini Mondal 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2018
卷号：8
期号：1
页码：420
DOI：10.1038/s41598-017-17981-z
语种：English
出版社：Springer Nature
摘要：expression, promoting endothelial adhesion and enhanced inhibition of xenogeneic aGVHD. These data indicate that the immature Treg glycome is under unique regulation and that adult PBMCs can be an ideal source of autologous-derived therapeutic Tregs, provided that subset selection and glycan engineering are engaged to optimize both their immunomodulation and tropism for inflammatory sites.