首页    期刊浏览 2024年11月30日 星期六
登录注册

文章基本信息

  • 标题:RGS7 is recurrently mutated in melanoma and promotes migration and invasion of human cancer cells
  • 本地全文:下载
  • 作者:Nouar Qutob ; Ikuo Masuho ; Michal Alon
  • 期刊名称:Scientific Reports
  • 电子版ISSN:2045-2322
  • 出版年度:2018
  • 卷号:8
  • 期号:1
  • 页码:653
  • DOI:10.1038/s41598-017-18851-4
  • 语种:English
  • 出版社:Springer Nature
  • 摘要:, thus providing a dual mechanism for its loss of function. Both of these effects are expected to contribute to loss of function of RGS7 resulting in increased anchorage-independent growth, migration and invasion of melanoma cells. By mutating position 56 in the R44C mutant from valine to cysteine, thereby enabling the formation of a disulfide bridge between the two mutated positions, we slightly increased the catalytic activity and reinstated protein stability, leading to the rescue of RGS7's function as a tumor suppressor. Our findings identify RGS7 as a novel melanoma driver and point to the clinical relevance of using strategies to stabilize the protein and, thereby, restore its function.
国家哲学社会科学文献中心版权所有