文章基本信息

标题：Dual functional dinuclear platinum complex with selective reactivity towards c-myc G-quadruplex
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作者：Lei He ; Zhenyu Meng ; Dechen Xu 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2018
卷号：8
期号：1
页码：767
DOI：10.1038/s41598-017-19095-y
语种：English
出版社：Springer Nature
摘要：(Dip: 4,7-diphenyl-1,10-phenanthroline), were designed to contain two dual-functional Pt cores connected by an alkyl linkage. Pt3 with nonanediamine linkage optimized the specific binding towards c-myc G-quadruplex via dual functional clamp on GQ as 1) non-covalently π-stacking of aromatic ligands, and 2) two Pt(II) cores covalently chelated to guanines at both 3'- and 5'-ends.