文章基本信息

标题：PERK-mediated translational control is required for collagen secretion in chondrocytes
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作者：Satoshi Hisanaga ; Masato Miyake ; Shusuke Taniuchi 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2018
卷号：8
期号：1
页码：773
DOI：10.1038/s41598-017-19052-9
语种：English
出版社：Springer Nature
摘要：mice displayed reduced collagen in articular cartilage but no differences in chondrocyte proliferation or apoptosis compared to the findings in wild-type mice. PERK inhibition increases misfolded protein levels in the ER, which largely hinder ER-to-Golgi transport. These results suggest that the translational control mediated by PERK is a critical determinant of ECM secretion in chondrocytes.