文章基本信息

标题：Foxo1 Promotes Th9 Cell Differentiation and Airway Allergy
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作者：Thomas S. Buttrick ; Wei Wang ; Christina Yung 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2018
卷号：8
期号：1
页码：818
DOI：10.1038/s41598-018-19315-z
语种：English
出版社：Springer Nature
摘要：T cells caused a reduction in IL-9 expression while upregulating IL-17A and IFNγ production. Furthermore, chromatin immunoprecipitation (ChIP) followed by luciferase assays revealed direct binding of Foxo1 to both the Il9 and Irf4 promoters and induces their transactivation. Lastly, adoptive transfer of Th9 cells into lungs induced asthma-like symptoms that were ameliorated by Foxo1 inhibitor, AS1842856. Together, our findings demonstrate a novel regulator of Th9 cells with a direct implication in allergic inflammation.