文章基本信息

标题：Areca nut extracts mobilize calcium and release pro-inflammatory cytokines from various immune cells
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作者：Malika Faouzi ; Ram P. Neupane ; Jian Yang 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2018
卷号：8
期号：1
页码：1075
DOI：10.1038/s41598-017-18996-2
语种：English
出版社：Springer Nature
摘要：signals, suggesting that the active components might represent novel or so far unappreciated chemical structures. The separation of ANE into aqueous and organic fractions has further revealed that the calcium-mobilizing molecules are exclusively present in the aqueous extract. In addition, we found that these calcium signals are associated with the activation of several immune cell lines as shown by the release of pro-inflammatory cytokines and increased cell proliferation. These results indicate that calcium-mobilizing molecules present in the aqueous fraction of the Areca nut may critically contribute to the inflammatory disorders affecting betel nut chewers.