文章基本信息

标题：Olfactory receptors are expressed in pancreatic β-cells and promote glucose-stimulated insulin secretion
本地全文：下载
作者：Yuichiro Munakata ; Tetsuya Yamada ; Junta Imai 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2018
卷号：8
期号：1
页码：1499
DOI：10.1038/s41598-018-19765-5
语种：English
出版社：Springer Nature
摘要：expression was not detectable in β-cells, experiments using inhibitors and siRNA revealed that the pathway dependent on phospholipase C-inositol triphosphate, rather than cAMP-protein kinase A, mediates GSIS potentiation via OLFR15. These findings suggest that the OR system in pancreatic β-cells has a chemo-sensor function allowing recognition of environmental substances obtained from food, and potentiates insulin secretion in a cell-autonomous manner, thereby modulating systemic glucose metabolism.