文章基本信息

标题：The Altered Supramolecular Structure of Dopamine D2 Receptors in Disc1-deficient Mice
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作者：Taichi Onishi ; Hirokazu Sakamoto ; Shigeyuki Namiki 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2018
卷号：8
期号：1
页码：1692
DOI：10.1038/s41598-018-20090-0
语种：English
出版社：Springer Nature
摘要：), and that Disc1-deficient mice have larger and more D2R nanoclusters than wild-type mice. Interestingly, administration of clozapine reduced the size and spatial distribution of the nanoclusters only in Disc1-deficient mice. Moreover, we observed that medium spiny neurons in the NAc of Disc1-deficient mice had reduced spine density on their dendrites than did wild-type mice, and this was also reversed by clozapine administration. The altered D2R nanoclusters might be morphological representations of the altered dopaminergic transmission in disease states such as schizophrenia.