文章基本信息

标题：The intrinsically disordered Tarp protein from chlamydia binds actin with a partially preformed helix
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作者：James Tolchard ; Samuel J. Walpole ; Andrew J. Miles 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2018
卷号：8
期号：1
页码：1960
DOI：10.1038/s41598-018-20290-8
语种：English
出版社：Springer Nature
摘要：of 102 nM, whilst synchrotron radiation circular dichroism spectroscopy suggests the binding is concomitant with an increase in helical secondary structure. Furthermore, NMR experiments in the presence of G-actin indicate this interaction affects the proposed WH2-like α-helical region, supporting results from in silico docking calculations which suggest that, when folded, this α-helix binds within the actin hydrophobic cleft as seen for other actin-associated proteins.