文章基本信息

标题：Serendipitous Discovery of a Guanine-rich DNA Molecule with a Highly Stable Structure in Urea
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作者：Wenqing Zhang ; Meng Liu ; Christine Lee 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2018
卷号：8
期号：1
页码：1935
DOI：10.1038/s41598-018-20248-w
语种：English
出版社：Springer Nature
摘要：and the folded structure remains stable when subjected to denaturing (7MU) polyacrylamide gel electrophoresis. Results from sequence mutagenesis, DNA methylation, and circular dichroism spectroscopy studies suggest that this molecule adopts an intramolecular guanine-quadruplex structure with 5 layers of guanine tetrads. Our finding indicates that DNA has the ability to create extremely stable structural folds despite its limited chemical repertoire, making it possible to develop DNA-based systems for unconventional applications.