文章基本信息

标题：TDP-43 self-interaction is modulated by redox-active compounds Auranofin, Chelerythrine and Riluzole
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作者：Moritz Oberstadt ; Jens Stieler ; David Larbi Simpong 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2018
卷号：8
期号：1
页码：2248
DOI：10.1038/s41598-018-20565-0
语种：English
出版社：Springer Nature
摘要：library identified auranofin, chelerythrine and riluzole as dose-dependent inhibitors of TDP-43 self-interaction. Further analysis of drug action of the gold-containing thioredoxin reductase inhibitor auranofin revealed a redistribution from insoluble TDP-43 protein pool to PBS-soluble protein pool in N2a cells. In addition, auranofin treatment diminished reduced glutathione as a sign for oxidative modulation.