文章基本信息

标题：Augmentation of CD134 (OX40)-dependent NK anti-tumour activity is dependent on antibody cross-linking
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作者：Anna H. Turaj ; Kerry L. Cox ; Christine A. Penfold 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2018
卷号：8
期号：1
页码：2278
DOI：10.1038/s41598-018-20656-y
语种：English
出版社：Springer Nature
摘要：lymphoma into immunocompetent syngeneic mice resulted in transient upregulation of CD134 on NK cells. Combination treatment with anti-CD20 and anti-CD134 mAb produced a synergistic effect with durable remissions. This therapeutic benefit was abrogated by NK cell depletion and in Fcγ chain -/- mice. Hence, anti-CD134 agonists may enhance NK-mediated anti-tumour activity in an Fcγ receptor dependent fashion.