文章基本信息

标题：Compositional marker in vivo reveals intramyocellular lipid turnover during fasting-induced lipolysis
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作者：Ajay Thankamony ; Graham J. Kemp ; Albert Koulman 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2018
卷号：8
期号：1
页码：2750
DOI：10.1038/s41598-018-21170-x
语种：English
出版社：Springer Nature
摘要：ratio indicated a less unsaturated IMCL pool after fasting, and this compositional change related inversely to IMCL baseline composition, suggesting a selective efflux of unsaturated shorter-chain FA from the IMCL pool. This novel in vivo evidence reveals IMCL turnover during extended fasting, consistent with the concept of a flexible, responsive myocellular lipid store. There were also differences between soleus and tibialis anterior in basal IMCL composition and in response to fasting. We discuss the potential of this marker for providing insights into normal physiology and mechanisms of disease.