文章基本信息

标题：Reverse Engineering the Intracellular Self-Assembly of a Functional Mechanopharmaceutical Device
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作者：Tehetina Woldemichael ; Rahul K. Keswani ; Phillip M. Rzeczycki 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2018
卷号：8
期号：1
页码：2934
DOI：10.1038/s41598-018-21271-7
语种：English
出版社：Springer Nature
摘要：of the weakly basic building block and its affinity for chloride, both of which are consistent with the pH and chloride content of a physiological lysosomal microenvironment. Most importantly, in vitro and in silico studies revealed that high expression levels of the vacuolar ATPase (V-ATPase), irrespective of the expression levels of chloride channels, are necessary and sufficient to explain the cell-type dependent formation, stabilization, and biocompatibility of the self-assembled mechanopharmaceutical device within macrophages.