文章基本信息

标题：Inactivation of TRPM7 kinase in mice results in enlarged spleens, reduced T-cell proliferation and diminished store-operated calcium entry
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作者：Pavani Beesetty ; Krystyna B. Wieczerzak ; Jennifer N. Gibson 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2018
卷号：8
期号：1
页码：3023
DOI：10.1038/s41598-018-21004-w
语种：English
出版社：Springer Nature
摘要：elevations elicited by anti-CD3 antibody were diminished in KD mutant T cells and SOCE measured in activated KD splenocytes was reduced. These results demonstrate that a functional TRPM7 kinase supports robust SOCE, blastogenesis and proliferation, whereas its inactivation suppresses these cellular events.