文章基本信息

标题：Delivery of exogenous mitochondria via centrifugation enhances cellular metabolic function
本地全文：下载
作者：Mi Jin Kim ; Jung Wook Hwang ; Chang-Koo Yun 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2018
卷号：8
期号：1
页码：3330
DOI：10.1038/s41598-018-21539-y
语种：English
出版社：Springer Nature
摘要：cells and dexamethasone-treated atrophic muscle cells. We found that mitochondrial transfer normalised ATP production, mitochondrial membrane potential, mitochondrial reactive oxygen species level, and the oxygen consumption rate of the target cells. Furthermore, delivery of intact mitochondria blocked the AMPK/FoxO3/Atrogene pathway underlying muscle atrophy in atrophic muscle cells. Taken together, this simple and rapid mitochondrial transfer method can be used to treat mitochondrial dysfunction-related diseases.