文章基本信息

标题：HDAC4 regulates satellite cell proliferation and differentiation by targeting P21 and Sharp1 genes
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作者：Nicoletta Marroncelli ; Marzia Bianchi ; Marco Bertin 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2018
卷号：8
期号：1
页码：3448
DOI：10.1038/s41598-018-21835-7
语种：English
出版社：Springer Nature
摘要：cells (HDAC4 KO mice). We found that the proliferation and differentiation of HDAC4 KO satellite cells were compromised, although similar amounts of satellite cells were found in mice. Moreover, we found that the inhibition of HDAC4 in satellite cells was sufficient to block the differentiation process. By RNA-sequencing analysis we identified P21 and Sharp1 as HDAC4 target genes. Reducing the expression of these target genes in HDAC4 KO satellite cells, we also defined the molecular pathways regulated by HDAC4 in the epigenetic control of satellite cell expansion and fusion.