文章基本信息

标题：Nanodelivery of a functional membrane receptor to manipulate cellular phenotype
本地全文：下载
作者：Tommaso Patriarchi ; Ao Shen ; Wei He 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2018
卷号：8
期号：1
页码：3556
DOI：10.1038/s41598-018-21863-3
语种：English
出版社：Springer Nature
摘要：AR into a variety of mammalian cells, which imparts pharmacologic control over cellular signaling and affects cellular phenotype in an ex-vivo wound-healing model. Our approach for nanodelivery of functional membrane receptors expands the current toolkit for DNA and RNA-free manipulation of cellular function. We expect this approach to be readily applicable to the synthesis and nanodelivery of other types of GPCRs and membrane receptors, opening new doors for therapeutic development at the intersection between synthetic biology and nanomedicine.