文章基本信息

标题：Elastic net regularized regression for time-series analysis of plasma metabolome stability under sub-optimal freezing condition
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作者：Gerard Bryan Gonzales ; Sarah De Saeger
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2018
卷号：8
期号：1
页码：3659
DOI：10.1038/s41598-018-21851-7
语种：English
出版社：Springer Nature
摘要：= 0.7893 [negative mode], p-value < 0.00001). Based on the temporal profiles of the extracted metabolites by the model, results show only minimal deterioration of the plasma metabolome at -20 °C up to 1 month. However, majority of the changes appeared at around 12-15 days of storage. This allows scientists to better plan logistics and storage strategies for samples obtained from low-resource settings, where -80 °C storage is not guaranteed.