文章基本信息

标题：An acute functional screen identifies an effective antibody targeting amyloid-β oligomers based on calcium imaging
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作者：Xueying Wang ; Ksenia V. Kastanenka ; Michal Arbel-Ornath 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2018
卷号：8
期号：1
页码：4634
DOI：10.1038/s41598-018-22979-2
语种：English
出版社：Springer Nature
摘要：in primary neuronal cultures, an effect prevented by ACU3B3. Topical application of 5 nM AβOs onto exposed cortical surfaces also elicited significant calcium elevations in vivo, which was completely abolished by pre-treatment of the brain with 1 ng/mL (6.67 pM) ACU3B3. Our results provide strong support for the utility of this functional screening assay in identifying and confirming the efficacy of AβO-blocking drug candidates such as the human homolog of ACU3B3, which may emerge as the first experimental AD therapeutic to validate the amyloid oligomer hypothesis.