文章基本信息

标题：The Effect of Obesity on the Availabilities of Dopamine and Serotonin Transporters
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作者：Su Bong Nam ; Keunyoung Kim ; Bum Soo Kim 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2018
卷号：8
期号：1
页码：4924
DOI：10.1038/s41598-018-22814-8
语种：English
出版社：Springer Nature
摘要：I-FP-CIT to DAT and SERT were calculated using regions of interest. Specific binding ratios (SBRs) of DAT and SERT except pons (r = 0.2217, p = 0.0026), were not correlated with body mass index (BMI). SBRs of midbrains correlated negatively with the BMIs of obese subjects (r = -0.3126, p = 0.0496), and positively with the those of non-obese subjects (r = 0.2327, p = 0.0053). SBRs of caudate nucleus (r = -0.3175, p < 0.0001), striatum (r = -0.226, p = 0.0022), and thalamus (r = -0.1978, p = 0.0074) reduced with age, and SERT availability was higher in males. However, DAT availability was similar in males and females. In conclusion, obesity has an effect on midbrain SERT availability. In addition, BMI was correlated with pontine SERT availability but not with striatal DAT availability. SERT availability was higher in males, but DAT availability showed no gender predilection.