文章基本信息

标题：Propagation-based phase-contrast x-ray tomography of cochlea using a compact synchrotron source
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作者：Mareike Töpperwien ; Regine Gradl ; Daniel Keppeler 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2018
卷号：8
期号：1
页码：4922
DOI：10.1038/s41598-018-23144-5
语种：English
出版社：Springer Nature
摘要：We demonstrate that phase retrieval and tomographic imaging at the organ level of small animals can be advantageously carried out using the monochromatic radiation emitted by a compact x-ray light source, without further optical elements apart from source and detector. This approach allows to carry out microtomography experiments which - due to the large performance gap with respect to conventional laboratory instruments - so far were usually limited to synchrotron sources. We demonstrate the potential by mapping the functional soft tissue within the guinea pig and marmoset cochlea, including in the latter case an electrical cochlear implant. We show how 3d microanatomical studies without dissection or microscopic imaging can enhance future research on cochlear implants.