文章基本信息

标题：A comparative analysis of rod bipolar cell transcriptomes identifies novel genes implicated in night vision
本地全文：下载
作者：Sasha M. Woods ; Edward Mountjoy ; Duncan Muir 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2018
卷号：8
期号：1
页码：5506
DOI：10.1038/s41598-018-23901-6
语种：English
出版社：Springer Nature
摘要：mouse retina (that lacks RBCs) to derive the RBC transcriptome. We found that genes expressed by adult RBCs are mainly involved in synaptic structure and signalling, whereas genes that influence RBC development are also involved in the cell cycle and transcription/translation. By comparing our data with other published retinal and bipolar cell transcriptomes (where we identify RBCs by the presence of Prkca and/or Pcp2 transcripts), we have derived a consensus for the adult RBC transcriptome. These findings ought to facilitate further research into physiological mechanisms underlying mammalian night vision as well as proposing candidate genes for patients with inherited causes of night blindness.