文章基本信息

标题：Activation of Calcium-Sensing Receptor increases intracellular calcium and decreases cAMP and mTOR in PKD1 deficient cells
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作者：Annarita Di Mise ; Grazia Tamma ; Marianna Ranieri 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2018
卷号：8
期号：1
页码：5704
DOI：10.1038/s41598-018-23732-5
语种：English
出版社：Springer Nature
摘要：, reduces intracellular cAMP and mTOR activity, reversing the principal dysregulations considered the most proximal events in ADPKD pathogenesis, making CaSR a possible candidate as therapeutic target.