文章基本信息

标题：IL-31 is crucial for induction of pruritus, but not inflammation, in contact hypersensitivity
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作者：Ayako Takamori ; Aya Nambu ; Keiko Sato 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2018
卷号：8
期号：1
页码：6639
DOI：10.1038/s41598-018-25094-4
语种：English
出版社：Springer Nature
摘要：) mice, which we newly generated. We demonstrated that the mice showed normal migration and maturation of skin dendritic cells and induction of hapten-specific T cells in the sensitization phase of FITC-induced CHS, and normal induction of local inflammation in the elicitation phase of FITC- and DNFB-induced CHS. On the other hand, those mice showed reduced scratching frequency and duration during FITC- and/or DNFB-induced CHS. Our findings suggest that IL-31 is responsible for pruritus, but not induction of local skin inflammation, during CHS induced by FITC and DNFB.