文章基本信息

标题：Discovery and functional characterisation of a luqin-type neuropeptide signalling system in a deuterostome
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作者：Luis Alfonso Yañez-Guerra ; Jérôme Delroisse ; Antón Barreiro-Iglesias 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2018
卷号：8
期号：1
页码：7220
DOI：10.1038/s41598-018-25606-2
语种：English
出版社：Springer Nature
摘要：) was identified as the ligand for two luqin-type receptors in A. rubens, ArLQR1 and ArLQR2. Furthermore, analysis of the expression of the ArLQ precursor using mRNA in situ hybridisation revealed expression in the nervous system, digestive system and locomotory organs (tube feet) and in vitro pharmacology revealed that ArLQ causes dose-dependent relaxation of tube feet. Accordingly, previous studies have revealed that luqin-type signalling regulates feeding and locomotor activity in protostomes. In conclusion, our phylogenetic analysis combined with characterisation of luqin-type signalling in a deuterostome has provided new insights into neuropeptide evolution and function in the animal kingdom.