文章基本信息

标题：FACS-Seq analysis of Pax3-derived cells identifies non-myogenic lineages in the embryonic forelimb
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作者：Arun J. Singh ; Chih-Ning Chang ; Hsiao-Yen Ma 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2018
卷号：8
期号：1
页码：7670
DOI：10.1038/s41598-018-25998-1
语种：English
出版社：Springer Nature
摘要：cells to construct gene networks involved in different stages of embryonic and fetal development. With this, we identified genes involved in the skeletal, muscular, vascular, nervous and immune systems. Expression of genes related to the immune, skeletal and vascular systems showed prominent increases over time, suggesting a non-skeletal myogenic context of Pax3-derived cells. Using co-expression analysis, we observed an immune-related gene subnetwork active during fetal myogenesis, further implying that Pax3-derived cells are not a strictly myogenic lineage, and are involved in patterning and three-dimensional formation of the forelimb through multiple systems.