文章基本信息

标题：Development and evaluation of a novel system for inducing orthostatic challenge by tilt tests and lower body negative pressure
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作者：Łukasz Dziuda ; Mariusz Krej ; Maciej Śmietanowski 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2018
卷号：8
期号：1
页码：7793
DOI：10.1038/s41598-018-26173-2
语种：English
出版社：Springer Nature
摘要：Lower body negative pressure (LBNP) is a method derived from space medicine, which in recent years has been increasingly used by clinicians to assess the efficiency of the cardiovascular regulatory mechanisms. LBNP with combined tilt testing is considered as an effective form of training to prevent orthostatic intolerance. We have developed a prototype system comprising a tilt table and LBNP chamber, and tested it in the context of the feasibility of the device for assessing the pilots' efficiency. The table allows for controlled tilting in the range from -45 to +80° at the maximum change rate of 45°/s. The LBNP value can smoothly be adjusted down to -100 mmHg at up to 20 mmHg/s. 17 subjects took part in the pilot study. A 24-minute scenario included -100 mmHg supine LBNP, head up tilt (HUT) and -60 mmHg LBNP associated with HUT, separated by resting phases. The most noticeable changes were observed in stroke volume (SV). During supine LBNP, HUT and the combined stimulus, a decrease of the SV value by 20%, 40% and below 50%, respectively, were detected. The proposed system can map any pre-programed tilt and LBNP profiles, and the pilot study confirmed the efficiency of performing experimental procedures.