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标题：Investigation of dose-rate effects and cell-cycle distribution under protracted exposure to ionizing radiation for various dose-rates
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作者：Yusuke Matsuya ; Stephen J. McMahon ; Kaori Tsutsumi 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2018
卷号：8
期号：1
页码：8287
DOI：10.1038/s41598-018-26556-5
语种：English
出版社：Springer Nature
摘要：/M phases is observed after exposure at 6.0 Gy/h for more than 10 hours. This suggests that an increase of SLDR rate for cells in S phase during irradiation may be a reproducible factor to describe changes in the dose-response curve at dose-rates of 3.0 and 6.0 Gy/h. By re-evaluating cell survival for various dose-rates of 0.186-60.0 Gy/h considering experimental-based DNA content and SLDR, it is suggested that the change of S phase fraction during irradiation modulates the dose-response curve and is possibly responsible for some inverse DREs.