文章基本信息

标题：Loss of periostin ameliorates adipose tissue inflammation and fibrosis in vivo
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作者：Fumiko Nakazeki ; Masataka Nishiga ; Takahiro Horie 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2018
卷号：8
期号：1
页码：8553
DOI：10.1038/s41598-018-27009-9
语种：English
出版社：Springer Nature
摘要：mice had lower levels of crown-like structure formation and fibrosis in adipose tissue and were protected from liver steatosis. These mice also showed amelioration in systemic insulin resistance compared with HFD-fed WT littermates. Mice deficient in Postn in their hematopoietic compartment also had lower levels of inflammation in adipose tissue, in parallel with a reduction in ectopic lipid accumulation compared with the controls. Our data indicated that the regulation of Postn in visceral fat could be beneficial for the maintenance of healthy adipose tissue in obesity.