文章基本信息

标题：Inhibition of the substantia nigra pars reticulata produces divergent effects on sensorimotor gating in rats and monkeys
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作者：Brittany L. Aguilar ; Patrick A. Forcelli ; Ludise Malkova 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2018
卷号：8
期号：1
页码：9369
DOI：10.1038/s41598-018-27577-w
语种：English
出版社：Springer Nature
摘要：agonist muscimol to investigate the role of SNpr in PPI. SNpr inactivation significantly disrupted PPI in rats, congruent with prior studies; however, in macaques, SNpr inactivation resulted in facilitation of PPI. We suggest that this difference in circuit function results from a divergence in anatomical connectivity, underscoring the importance of circuit dissection studies across species.