文章基本信息

标题：Characterization of influenza virus variants induced by treatment with the endonuclease inhibitor baloxavir marboxil
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作者：Shinya Omoto ; Valentina Speranzini ; Takashi Hashimoto 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2018
卷号：8
期号：1
页码：9633
DOI：10.1038/s41598-018-27890-4
语种：English
出版社：Springer Nature
摘要：changes in A and B viruses, respectively. The viruses harboring the I38T substitution show severely impaired replicative fitness in cells, and correspondingly reduced endonuclease activity in vitro. Co-crystal structures of wild-type and I38T influenza A and B endonucleases bound to BXA show that the mutation reduces van der Waals contacts with the inhibitor. A reduced affinity to the I38T mutant is supported by the lower stability of the BXA-bound endonuclease. These mechanistic insights provide markers for future surveillance of treated populations.