文章基本信息

标题：Antibody responses to α-Gal in African children vary with age and site and are associated with malaria protection
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作者：Ruth Aguilar ; Itziar Ubillos ; Marta Vidal 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2018
卷号：8
期号：1
页码：9999
DOI：10.1038/s41598-018-28325-w
语种：English
出版社：Springer Nature
摘要：levels vary mainly depending on the age of the child, and also differ in magnitude in the two sites. At an individual level, the intensity of malaria exposure to P. falciparum and maternally-transferred antibodies affected the magnitude of α-Gal responses. There was evidence for a possible protective role of anti-α-Gal IgG3 and IgG4 antibodies. However, the most consistent findings were that the magnitude of IgM responses to α-Gal was associated with protection against clinical malaria over a one-year follow up period, especially in the first months of life, while IgG levels correlated with malaria risk.