文章基本信息

标题：GABA promotes gastrin-releasing peptide secretion in NE/NE-like cells: Contribution to prostate cancer progression
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作者：Susana R. Solorzano ; Ivan Imaz-Rosshandler ; Ignacio Camacho-Arroyo 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2018
卷号：8
期号：1
页码：10272
DOI：10.1038/s41598-018-28538-z
语种：English
出版社：Springer Nature
摘要：receptor agonist. Moreover, the blocking of this receptor inhibited GABA-induced GRP secretion. The invasive potential of PC3 cells was enhanced by either GRP or conditioned medium of NE-like cells treated with GABA. Additionally, we confirmed a positive correlation between GABA and GRP levels in the serum of PCa patients with NE markers. Finally, using public available data sets, we found a negative correlation between GABBR1 and androgen receptor (AR) expression, as well as a strong positive correlation between GABBR1 and enolase 2. These results suggest that GABA via GABBR1 induces GRP secretion in NE like cells involved in PCa progression.