文章基本信息

标题：Unique Lipid Signatures of Extracellular Vesicles from the Airways of Asthmatics
本地全文：下载
作者：Kenneth P. Hough ; Landon S. Wilson ; Jennifer L. Trevor 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2018
卷号：8
期号：1
页码：10340
DOI：10.1038/s41598-018-28655-9
语种：English
出版社：Springer Nature
摘要：exosomes were also significantly higher in asthmatics. Lipidomics analysis revealed that phosphatidylglycerol, ceramide-phosphates, and ceramides were significantly reduced in exosomes from asthmatics compared to the non-exposed control groups. Sphingomyelin 34:1 was more abundant in exosomes of SHS-exposed asthmatics compared to healthy controls. Our results suggest that chronic airway inflammation may be driven by alterations in the composition of lipid mediators within airway EVs of human subjects with asthma.