文章基本信息

标题：Central insulin action induces activation of paraventricular oxytocin neurons to release oxytocin into circulation
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作者：Boyang Zhang ; Masanori Nakata ; Jun Nakae 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2018
卷号：8
期号：1
页码：10415
DOI：10.1038/s41598-018-28816-w
语种：English
出版社：Springer Nature
摘要：was markedly diminished in the larger-sized oxytocin neurons, while it was intact in the smaller-sized oxytocin neurons. Furthermore, intracerebroventricular insulin administration induced oxytocin release into plasma in Oxy Cre but not Oxy Pdk1 KO mice. These results demonstrate that insulin PDK1-dependently preferentially activates PVN magnocellular oxytocin neurons to release oxytocin into circulation, possibly serving as a mechanism for the interaction between metabolism and perinatal functions.