文章基本信息

标题：The thrombopoietin mimetic romiplostim leads to the complete rescue of mice exposed to lethal ionizing radiation
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作者：Masaru Yamaguchi ; Tokuhisa Hirouchi ; Koki Yokoyama 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2018
卷号：8
期号：1
页码：10659
DOI：10.1038/s41598-018-29013-5
语种：English
出版社：Springer Nature
摘要：Cs γ-rays, and all irradiated mice survived for more than 30 days with both 3- and 5-day consecutive administrations. By day 30, the peripheral blood cells, bone marrow cells and haematopoietic progenitor cells of the RP-administered irradiated mice had all recovered to a level that was not significantly different from that in non-irradiated mice. In contrast to myelosuppression, which did not fully recover until day 30, the expression of several bone marrow cell surface antigens recovered sooner, and DNA repair concurrently increased in haematopoietic cells, speeding the resolution of double strand breaks and reducing the rates of apoptosis. These findings suggest that RP may be a clinic-ready countermeasure to treat victims of radiation accidents.